COVID 19 is a global crisis, that disorganized almost every aspect of life in 2020 and left an impact on our future lives. Science based researchers are the most sufferers as the researches undertaken are either laboratory oriented or analytical aspects which require laboratory experiments which requires laboratory experiments but the pandemic slowed most academic activities down. Life unpredicted crisis most times are what forces human adaptation to changes, the change in this era reintroduced Problem based learning (e-learning and blended learning); a long-proposed means of learning which at the long run became a resort of learning during the pandemic; as studies with people were limited and almost impossible, so conducting online lectures became the uttermost alternative to learning. Face-to face learning is replaced with e-learning, though it also came with its own challenges whereby not all countries can manage for online teachings due to no access to internet as most students reside in rural areas with no electricity. What will the world of sciences and academia look like after COVID 19 pandemic? This article reflects on the need to acknowledge the NEW REALITY as an answer to the transition we already found ourselves in 2020. The obvious impact around the globes brought about several challenges in the scientific institutes; at the same time, it poses as what will trigger space for transformation. Scientific world such as universities and research laboratories are seen with rapid transformation already as researchers and young scientists are left with no choice than to reduce the experimental based studies and rather engage more on online scientific meetings and a renewed recognition of the value of distance learning. Keyword: Post COVID-19 era, New reality, E-learning, Scientific transformation and Lessons learnt