The phytochemical evaluation of leaf extracts of five medicinal plant species: Boerhavia diffusa, Cissus aralioides, Commelina benghalensis, Leucas martinicensis, and Senna occidentalis from Southeast zone of Nigeria, was conducted using standard procedures of Harborne.The results revealed that the plants are rich in important bioactive compounds occurring in varying concentrations as: alkaloids (2.42%,3.31%,1.82%,1.21%, and 2.23%);tannins (1.24%,10.20%, 17.78%,1.45%, and 2.04%); flavonoids (1.80%, 11.13%, 6.50%, 7.46%, and 1.67%); saponins (10.73%, 4.70%, 2.90%, 8.94%, and 13.48%); phenols (4.12mg/100g, 13.12mg/100g, 5.14mg/100g, 3.21mg/100g, and 4.38mg/100g); terpenoids (4.28%,15.16%,2.68%,4.85%,and 8.39%), and cardiac glycosides (0.13mg/l, 0.28mg/l, 0.81mg/l, 0.87mg/l, and 0.22mg/l) for Boerhavia diffusa, Cissus aralioides, Commelina benghalensis, Leucas martinicensis, and Senna occidentalis, respectively. Since these phytochemicals possess biological activities, they are therefore responsible for the medicinal uses of these plants .We recommend for further investigation of the detailed therapeutic properties of these plants and also the isolation, structural elucidation and full characterization of the specific phytoconstituents of the study plants. KEY WORDS: Evaluation, phytochemistry, medicinal plants, Nigeria.