Spices are plant parts or organs including fruits, seeds, roots and rhizomes, and other plant parts used for flavoring or coloring of food. The phytochemical assessment of some spices from Anambra State including Capsicum annuum L., Piper nigrumL., Xylopia aethiopica (Dunal) A. Rich. (Fruits), and Myristica fragrans Hoult. (Seeds) was conducted using standard procedures.The research mas motivated by the fact that these spices are greatly and frequently used in various dishes in Anambra State. The results indicated that the spices possessed anthraquinones, alkaloids, saponins, terpenoids, tannins, flavonoids, phenols, and cardiac glycosides in varying concentrations. Alkaloid was the highest with the value of 28.70% ± 0.2 while saponin followed having the value of 28.23% ± 0.3.The least was cardiac glycoside valued as 0.02 µg/100g ± 0.005. The presence of these bioactive compounds in the study spices confirms their use in traditional medicine. The rich contents o