This study focused on reducing ergonomic hazards and challenges in clothing laboratories in tertiary institution in Anambra State. The population for the study comprised of 1,752 students and laboratory assistants in tertiary institutions in Anambra State. Simple random sampling technique was used to select 140 students and laboratory assistants. Questionnaire was used for data collection. Data was analyzed using mean to answer research questions. The findings indicated that, repetitive movement, forceful movement, awkward postures, carrying heavy loads, and improper lifting methods were major ergonomic hazards in clothing laboratories, while, use of proper tools, avoidance of awkward postures, use of safe lifting procedures, and reduction of excessive force were strategies to minimize ergonomic hazards. Recommendations were made which include proper training of workers, providing safe work station, involvement of workers in decision making, provision of safety stan