Good governance has been seen as the promotion of accountability, efficiency, rule of law, and the fight against corruption. It encompasses participation, transparency, and equitability during the exercise of authority in a country. The focus of this paper was to examine the effect of good governance in Nigeria as it cushions the economy through science and technology. The study is fully dependent on secondary data. This study revealed that for good governance to be attained the government must adequately address insecurity, education, rural development, rule of law, press freedom, and fight against corruption. The study recommends that science and technology be pursued to enable the attainment of these goals. Knowledge is fundamental to human development, therefore, catalyses economic growth, social development, cultural enrichment and political sustainability. Keywords; Effective Governance, Nigeria and Economy, Science and Technology