Sweet potato (Ipomea batatas) is one of the most economically important species of tropical root and tuber crops, with percentage yield of 20.47% which can grow in abundance on marginal soils. The starch was extracted from the tuber and some amount of the extracted starch was enzymatically modified by enzyme ?-amylase. The starches were evaluated for their physicochemical properties; (pH, Moisture content, Iodine test, Acidity,), NPS and EHS were investigated and compared to the standard, Maize Starch. The native sweet potato starch (NPS) and Enzyme hydrolyzed starch (EHS) were used in the formulation of paracetamol tablet. Similarly the tablets were evaluated for it Hardness, friability, disintegration time and dissolution rate. The results showed that NPS and EHS were insoluble in water and alcohol (95%) at room temperature. NPS was more acidic than EHS and the standard. The pH of NPS was 5.98± 0.01 that of EHS was 6.23± 0.43 and pH of maize was 6.31± 0.34 which was within the standa