The paper discussed on the relevance of mathematics in science and technology, which in turn is beneficial for economic empowerment in Nigeria. Issues addressed in the paper are: need for economic empowerment in Nigeria, science and technology as a means of economic empowerment, potential of mathematics in science and technology, ensuring quality mathematics education. The paper pointed out that: the economic hardship in Nigeria, which is associated with unemployment, can be ameliorated through engaging in entrepreneurship for economic empowerment; science and technology is associated with economic empowerment because it is applied in provision of goods and services needed for generation of income, mathematics is relevant in enhancing operations in science and technology because mathematics serves as a language of science and technology; fostering effective use of mathematics in science and technology demands that all stakeholders in mathematics education should be diligent in ensuring